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Dr. Ralf Mueller is the Director of Chemistry of Alchem Laboratories Corporation. He obtained his Ph. D. in Organic Chemistry from the University of Freiburg, Germany, where he worked on the synthesis of spiro compounds by intramolecular 1,3-dipolar cycloaddition. Dr. Mueller then joined the Department of Medicinal Chemistry at the University of Florida, Gainesville, FL, as a Postdoctoral Associate and contributed significantly to the syntheses of the "Hypusine reagent" and a variety of hydroxylated polyamine analogs. He was employed by Alchem Laboratories in 2000 as a Senior Research Scientist and promoted to Group Leader, Synthetic Chemistry later that year.  As a result of his outstanding contributions as a group leader, he was promoted to Associate Director of Chemistry in 2004 and most recently to Director of Chemistry in 2006.

Recent Publications:

1)     Oniciu, D. C.; Pop, E.; Dasseux, J.-L. H.; Mueller, R.; Yang, J.; Bell, R. P. L.; Regeling, H.; Ebbers, E. J.; Leemhuis, F. M. C.; Cramer, C. T.; Goetz, B.; Pape, M. E.; Bisgaier, C. L. Long hydrocarbon chain diols and diacids with central ether or ketone moieties that favorably alter lipid disorders. Pharmazie 2006, 61, 157-165.

2)   Oniciu, D. C.; Bell, R. P. L.; McCosar, B. H.; Bisgaier, C. L.; Dasseux, J.-L. H.; Verdijk, D.; Relou, M.; Smith, D.; Regeling, H.; Leemhuis, F. M. C.; Ebbers, E. J.; Mueller, R.; Zhang, L.; Pop, E.; Cramer, C. T.; Goetz, B.; McKee, A.; Pape, M. E.; Krause, B. R. Syntheses of Pantolactone and Pantothenic Acid Derivatives as Potential Lipid Regulating Agents. Synth. Commun. 2006, 36, 365-391.

3)     Oniciu, D. C.; Dasseux, J.-L. H.; Yang, J.; Mueller, R.; Pop, E.; Denysenko, A.; Duan, C.; Huang, T.-B.; Zhang, L.; Krause, B. R.; Drake, S. L.; Lalwani, N.; Cramer, C. T.; Goetz, B.; Pape, M. E.; McKee, A.; Fici, G. J.; Lutostanski, J. M.; Brown, S. C.; Bisgaier, C. L.  Influence of Various Central Moieties on the Hypolipidemic Properties of Long Hydrocarbon Chain Diols and Diacids. J. Med. Chem. 2006, 49, 334-348.

4)    Yang, J.; Mueller, R.; Pop, E.; Dasseux, J.-L. H.; Oniciu; D. C. Kilogram-Scale Synthesis of Bis(6-hydroxy-5,5-dimethylhexyl)ether (ESP24232), a Novel Lipid Lowering Agent. Org. Prep. Proc. Int. 2004, 36, 587-596.

5)     Mueller, R.; Yang, J.; Duan, C.; Pop, E.; Geoffroy, O. J.; Zhang, L. H.; Huang, T.-B.; Denisenko, S.; McCosar, B. H.; Oniciu, D. C.; Bisgaier, C. L.; Pape, M. E.; Freiman, C. D.; Goetz, B.; Cramer, C. T.; Hopson, K. L.; Dasseux, J.-L. H. Long Hydrocarbon Chain Keto Diols and Diacids that Favorably Alter Disorders In Vivo”. J. Med. Chem. 2004, 47, 6082-6099.

6)     Mueller, R.; Yang, J.; Duan, C.; Pop, E.; Zhang, L. H.; Huang, T.-B.; Denysenko, A.; Denisko, O. V.; Oniciu, D. C.; Bisgaier, C. L.; Pape, M. E.; Freiman, C. D.; Goetz, B.; Cramer, C. T.; Hopson, K. L.; Dasseux, J.-L. H. Long Hydrocarbon Chain Ether Diols and Ether Diacids that Favorably Alter Lipid Disorders In Vivo. J. Med. Chem. 2004, 47, 5183-5197.

7)     Bergeron, R. J.; Mueller, R.; McManis, J. S.; Yao, G. W.; Huang, G. An Improved Synthesis of (3S,12S)-N¹,N¹⁴-Diethyl-3,12-dihydroxyhomospermine, a Polyamine Analogue Therapeutic Agent. Synthesis 2001, 1043-1048.

8)     Bergeron, R. J.; Mueller, R.; Bussenius, J.; McManis, J. S.; Merriman, R. L.; Smith, R.E.; Yao, H.; Weimar, W. R. Synthesis and Evaluation of Hydroxylated Polyamine Analogues as Antiproliferatives. J. Med. Chem. 2000, 43, 224-235.

9)     Bergeron, R. J.; Bussenius, J.; Mueller, R.; McCosar, B. H.; McManis, J. S. (R)- and (S)-N-(Benzyloxycarbonyl)-3,4-epoxybutylamine. New 4-amino-2-hydroxybutyl synthons for the synthesis of the hypusine reagents and (R)-6- and (S)-7-hydroxyspermidine. Tetrahedron: Asymmetry 1999, 10, 4285-4294.

10)  Bergeron, R. J.; Weimar, W. R.; Mueller, R.; Zimmerman, C. O.; McCosar, B. H.; Yao, H.; Smith, R. E. Synthesis of Reagents for the Construction of Hypusine and Deoxyhypusine Peptides and Their Application as Peptidic Antigens. J. Med. Chem. 1998, 41, 3888-3900.

11)  Bergeron, R. J.; Weimar, W. R.; Mueller, R.; Zimmerman, C. O.; McCosar, B. H.; Yao, H.; Smith, R. E. Effect of Polyamine Analogues on Hypusine Content in JURKAT T-Cells. J. Med. Chem. 1998, 41, 3901-3908.

12)  Bergeron, R. J.; Ludin, C.; Mueller, R.; Smith, R. E.; Phanstiel, IV, O. Development of a Hypusine Reagent for Peptide Synthesis. J. Org. Chem. 1997, 62, 3285-3290.