| J. Yang, R. Mueller, E. Pop,
J.-L. H. Dasseux, D. Oniciu, Kilogram-Scale Synthesis of
Bis(6-hydroxy-5,5-dimethylhexyl)ether (ESP24232), a Novel Lipid Lowering Agent. Org. Prep.
Proc. Int. 587-596, 36 (2004). E. Pop, D. C.
Oniciu, M. E. Pape, C. T. Cramer, J.-L. H. Dasseux, Lipophilicity Parameters and
Biological Activity in a Series of Compounds with Potential Cardiovascular
Application. Croatica Chim. Acta, 301-306, 77 (2004).
R. Mueller, J. Yang, C. Duan, E. Pop, O. J. Geoffroy, L. H.
Zhang, T.-B. Huang, S. Denisenko, B. H. McCosar, D. C. Oniciu, C. L. Bisgaier, M. E. Pape,
C. D. Freiman, B. Goetz, C. T. Cramer, K. L. Hopson, J.-L. H. Dasseux, Long
Hydrocarbon Chain Keto-Diols and Diacids that Favorably Alter Disorders In Vivo. J.
Med. Chem., 6082-6099, 47 (2004).
R. Mueller, J. Yang, C. Duan, E. Pop, L. H. Zhang, T.-B.
Huang, A. Denysenko, O. Denisko, D. C. Oniciu, C. L. Bisgaier, M. E. Pape, C. D.Freiman,
B. Goetz, C. T. Cramer, K. L. Hopson. J.-L. H. Dasseux. Long Hydrocarbon Chain
Ether-Diols and Ether Diacids that Favorably Alter Lipid Disorders In Vivo. J. Med.
Chem. 5183-5197, 47 (2004).
E. Pop, Pharmacology and Medicinal Chemistry of
THC in Cannabinoids (Landes Bioscience), V. Di Marzo (Ed), pp.8-32; (2004). ISBN:
1-58706-214-3.
V. Di Marzo and E. Pop, The Chemical Constituents of
Cannabis Sativa in Cannabinoids V. Di Marzo (Ed), (Landes Bioscience/Eurekah.com,
Georgetown, Texas; Kluver Academic/Plenum Publishers, New York, NY), pp 1-8 (2004).
E. Pop Current Trends In Neuroprotection,
Archivos de la Societad Espanola de Oftalmologia, 77, 295-298 (2002).
E. Pop and P. Buchwald, Attempts of Ranking in a Series
of Synthetic Nonpsychotropic Cannabinoids, SARQSAR Environ. Res. 12, 113-127 (2001).
E. Pop, Dexanabinol, Current Opinion in
Investigational Drugs, 1 (4) 494-503 (2000).
E. Pop, Synthetic Cannabinoids, Potential Therapeutic
Agents for the Central Nervous System, European Neuropsychopharmacology, 10,
S184-185 (2000).
E. Pop, Nonpsychotropic Synthetic Cannabinoids,
Current Pharmaceutical Design, 6, 1347 - 1360 (2000).
E. Pop, Synthetic Cannabinoids - Preface, Current
Pharmaceutical Design, 6 (2000).
E. Pop, Contributions to the Chemistry of Synthetic
Cannabinoids, Roumanian Chemical Quarterly Reviews, 8, 19-44 (2000).
E. Pop, Water-Soluble Combinations of Dexanabinol:
Prodrugs and Analogs, Die Pharmazie, 55, 167-171 (2000).
E. Pop, F. Soti, S. Rachwal, Hemiesters of Dexanabinol
and Their Water- Soluble Salts, Org. Prep. Proc. Int. 31, 565-570 (1999).
E. Pop, Developing Cannabinoids as Potential Central
Nervous System AgentsCurrent Opinion Central and Peripheral Nervous System
Investigational Drugs (COCPNS) 1, 587-596 (1999).
E. Pop, Cannabinoids, Endogenous Ligands and Synthetic
Analogs, Current Opinion in Chemical Biology, 3, 418-425 (1999).
E. Pop, S. Rachwal, J. Vlasak, A. Biegon, A. Zharikova and
L.Prokai, "In Vitro and In Vivo Study of Some Water Soluble Prodrugs of
Dexanabinol", J. Pharm. Sci., 88, 1156-1160 (1999).
E. Pop, S. Rachwal, J. Vlasak, M. E. Brewster , L. Prokai and
A. Biegon, "Quaternary Ammonium Moiety Containing Water Soluble Amino Acid Ester-
Type Prodrugs of Dexanabinol" Proc. 2-nd World Meeting on Pharmaceutics,
Biopharmaceutics Pharmaceutical Technology. Paris, pp. 101-102 (1998).
S. Rachwal, P. Druzgala, Z. Z. Liu, J. Vlasak and E. Pop,
"Chemistry of Loteprednol Etabonate and Related Steroids. II. Reactions at Ring C and
NMR Structural Studies od the Resulting Compounds", Steroids, 63, 193-201 (1998).
E. Pop, "Optimization of the Properties of Brain
Specific Chemical Delivery Systems by Structural Modifications", Current Medicinal
Chemistry, 4, 279-294 (1997).
E. Pop, B. Rachwal, S. Rachwal J. Vlasak, L. Prokai and M.E.
Brewster, "Synthesis of Labeled Dexanabinol, a Nonpsychotropic Cannabinoid with
Neuroprotective Properties", Journal of Labelled Compounds and Radiopharmaceuticals,
XLI, 885-897 (1998).
E. Pop and M. E. Brewster, "Dimerization of Dexanabinol
by Hydrogen Bonding Accounts for its Hydrophobic Character", Int. J. Quantum Chem.,
Quantum Biology Symposium 24, 65, 1057-64 (1997).
M. E. Brewster, E. Pop, R. Foltz, W. Griffith, S. Amselem and
A. Biegon, "Clinical Pharmacokinetics of Escalating I.V. Doses of Dexanabinol
(HU-211), a Neuroprotectant Agent, in Normal Volunteers", J. Clin. Pharmacol. and
Therapeutics, 35, 361-365 (1997).
T. Siegal, F. Soti, A. Biegon, E. Pop and M. E. Brewster,
"Effect of a Chemical Delivery System for Dexamethasone (Dex-CDS) on Peritumoral
Edema in Implanted Brain Cancer in Rats", Pharm. Res., 14, 672-675 (1997).
M. E. Brewster, Y. Paran, A. Horwitz, R. Margalit, E.
Rushkin, A. Biegon, E. Pop and H. Degani, "Evaluation of the Anticancer Action of a
Permanently Charged Tamoxifen Derivative, Tamoxifen Methiodide: an MRI Study", Int.
J. Pharmaceutics, 153, 147-157 (1997).
M. E. Brewster, W. R. Anderson, D. Meinsma, D. Moreno, A.
Webb, L. Pablo, K. Estes, H. Derendorf, N. Bodor, R. Sawchuk, B. Cheng and E. Pop,
"Intravenous and Oral Pharmacokinetic Evaluation of a 2-Hydroxypropyl-
-Cyclodextrin-based Formulation of Carbamazepine in the Dog: Comparison with Commercially
Available Tablets and Suspensions", J. Pharm. Sci., 86, 335-339 (1997).
M. E. Brewster, W. Anderson, A. Webb, D. Meinsma, D. Marino,
H. Derendorf, N. Bodor and E. Pop, "Evaluation of a Brain Targeting Zidovudine
Chemical Delivery System in the Dog", Antimicrobial Agents & Chemotherapy, 41,
122-128 (1997).
E. Pop, F. Soti, A. Biegon and M. E. Brewster, " Allylic
and Phenolic Phosphate Esters of Dexanabinol. Org. Prep. Proc. Int., 29, 341-347 (1997).
E. Pop, C. E. Browne, V. Nadler, A. Biegon and M. E.
Brewster, "Neuroprotective (+) 3S, 4S Cannabinoids with Modified 5'-Side Chain",
Bioorg. & Med.Chem.Lett. 6, 1553-1558 (1996).
M. E. Brewster, W. Anderson, T. Loftsson, N. Bodor and E.
Pop, "Effects of 2- Hydroxypropyl-cyclodextrin Complexes of the Neurosteroids,
Alfaxolone, Proceedings of The 8-th International Symposium on Cyclodextrin, pp. 511 -
514, Szejtli, J. and Szente, L. (Eds.), Kluwer Academic Publishers, Dordecht, Netherlands
(1996).
M. E. Brewster, J. Howes, A. Harris, W. Griffith, N. Garty,
N. Bodor and E. Pop, "Intravenous and Buccal 2-Hydroxypropyl- -cyclodextrin
Formulation of E2-CDS- Phase I Clinical Trials". Proceedings of The 8-th
International Symposium on Cyclodextrin, pp. 507 -510, Szejtli, J. and Szente, L. (Eds.),
Kluwer Academic Publishers, Dordecht, Netherlands pp. (1996).
M. E. Brewster, T. Murakami, W. R. Anderson, N. Bodor and E.
Pop, "Improved Oral Bioavailability of the Brain-Targeting Estrogen, E2-CDS, through
the Use of Carboxymethylethyl- -cyclodextrin". Proceedings of The 8-th International
Symposium on Cyclodextrin, pp. 503 - 506, Szejtli, J. and Szente, L. (Eds.), Kluwer
Academic Publishers, Dordecht, Netherlands (1996).
M. E. Brewster, W. Anderson, A. Webb, N. Bodor and E. Pop,
" Anesthetic Activity and Pharmacokinetics of the Neurosteroid Alfaxolone Formulated
in 2-Hydroxypropyl- -Cyclodextrin in the Rat". Proceedings of The 8-the International
Symposium on Cyclodextrin, pp. 499 - 502, Szejtli, J. and Szente, L. (Eds.), Kluwer
Academic Publishers, Dordecht, Netherlands (1996).
M. E. Brewster, W. R. Anderson and E. Pop, "Effect of
Sustained Estradiol Release in the Intact Male Rat: Correlation of Estradiol Serum Levels
with Effects on Body Weight, Serum Testosterone and Peripheral Androgen-Dependent
Tissues", Physiology and Behavior, 61, 225-229 (1997).
E.Pop, S.Rachwal and M.E.Brewster, "On the Allylic
Rearrangement of the trans-Pinocarveol Esters to Myrtenol Esters", Int. J. Quantum
Chem., Quantum Biol. Symposium 23, 1829-1834 (1996).
M. E. Brewster, M.-J. Huang, N. Bodor and E. Pop, " An
AM1-Based Model System for Estimation of Brain/Blood Concentration Ratios", Int. J.
Quantum Chem., Quantum Biol. Symposium 23, 1775-1787 (1996).
A. Biegon, M.E. Brewster, H. Degani, E. Pop, D.Somjen and A.
Kaye, "A Permanently Charged Tamoxifen Derivative Displays Anti-Cancer Activity and
Improved Tissue Selectivity in Rodents." Cancer Research, 56, 4328-4331 (1996).
S. Rachwal, E. Pop and M.E. Brewster, "Independent Total
Assignment of the 1H and 13C NMR Spectra of Loteprednol Etabonate." Steroids, 61,
524-530 (1996).
E. Pop, F. Soti, W. Anderson, J.A. Panetta, K.S. Estes, N.
Bodor and M.E. Brewster, "Brain Specific Delivery Systems of LY231617, an Antioxidant
with Potential Use in the Treatment of Brain Damage". Int. J. Pharm., 140, 33-44
(1996).
C.T. Supuran, M. Barboiu, C. Luca, E. Pop, M.E. Brewster and
A. Dinculescu." Carbonic Anyhdrase Activators 14. Synthesis of Positively Charged
Derivatives of 2-Amino-5-(2-aminoethyl) and 2-Amino-5-(2-aminopropyl)-1,3,4-thiadiazole
and their Interaction with Isozyme II". Eur. J. Med. Chem., 31, 597-606 (1996).
E. Pop, F. Soti, M. E. Brewster, Y. Barenholz, R. Mechoulam,
V. Nadler and A. Biegon, "Derivatives of Dexanabinol. II. Salts of Aminoacid Esters
Containing Tertiary and Quaternary Cyclic Nitrogen with Increased Water-Solubility."
Pharm. Res., 13, 469-475 (1996).
E. Pop, Z.Z. Liu, M.E. Brewster, Y. Barenholz, V. Korablyov,
R. Mechoulam, V. Nadler and A. Biegon, "Derivatives of Dexanabinol. I. Water-Soluble
Salts of Glycinate Esters." Pharm. Res., 13, 62-69 (1996).
M.E. Brewster, W.R. Anderson, T. Loftsson, N. Bodor and E.
Pop, "Preparation and Pharmacological Properties of 2-Hydroxypropyl- -cyclodextrin
Complexes of Pregnanolone and Pregnenolone." J. Pharm. Sci., 84, 1154-1159 (1995).
E. Pop, F. Soti, and M.E. Brewster, "A Simple Procedure
for Selective Acylation of the Less Reactive Hydroxyl Functionality in Some Dihydroxylated
Compounds." Synth. Commun., 25, 4099-4106 (1995).
M.-J Huang, D. Doerge, N. Bodor, E. Pop and M.E. Brewster,
"Nitrogen Radical Cations and Intermediates in Enzymatically Mediated Oxidative
Deaminations - Molecular Versus Fragment Approaches." Int. J. Quantum Chem., Quantum
Biol. Symposium, 22, 171-179 (1995).
M.E. Brewster, M.-J Huang, C. Browne, N. Bodor, E. Pop and
A.T. Balaban, "Relative Reactivity of 1,4- and 1,6-dihydronicotinic Acid Derivatives
to Radically Mediated Oxidation - a Theoretical and Experimental Evaluation". Int J.
Quantum, Chem., Quantum Biol Symposium, 22, 161-170 (1995).
E. Pop, M.-J Huang, N. Bodor and M.E. Brewster,
"Hydrolytic Stability of Allylic and Phenolic Esters of Some Synthetic Cannabinoids;
a Theoretical (AM1) Study" Int. J. Quantum. Chem. Quantum Biol. Symposium, 22,
137-143 (1995).
E. Pop, M.E. Brewster, Z.Z. Liu, F. Soti, S. Rachwal, A.
Dinculescu, V. Nadler, Y. Barenholz, R. Mechoulam and A. Biegon, "Water Soluble
Prodrugs and Congeners of Dexanabinol." Proceedings of the 1st World Meeting on
Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Budapest, pp. 127-128
(1995).
M. Brewster, W. Anderson, E. Pop, R. Sawchuck, B. Cheung and
A. Webb, " Improved Oral Bioavailability of Carbamazepine through the Use of
Chemically Modified Cyclodextrins." Proceedings of the 1st World Meeting on
Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Budapest, pp. 627-628
(1995).
M. Brewster, W. Anderson, E. Pop, N. Bodor and A. Webb,
"Dog Pharmacokinetics of Zidovudine and a Zidovudine Chemical Delivery System."
Proceedings of the 1st World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical
Technology, Budapest, pp. 905-906 (1995).
E. Pop, Z.Z. Liu, J. Vlasak, W.R. Anderson, N. Bodor and M.E.
Brewster, "Synthesis and Evaluation of a Novel Chemical Delivery System of Zidovudine
with Increased Stability at Low pH." Pharm. Sci., 1, 265-269 (1995).
M.E. Brewster, W.R. Anderson, K.S. Estes, N.S, Bodor, E. Pop
and J.A. Panetta, "Tissue Distribution of LY231617, an Antioxidant with
Neuroprotectant Activity, in the Rat." J. Pharm. Sci., 84, 791-793 (1995).
E. Pop, M.E. Brewster, M.-J. Huang and N. Bodor,
"Substituent Effects on the Stability of 1,4-Dihydropyridines" J. Mol. Structure
(Theochem), 337, 49-55 (1995).
M.E. Brewster, W. R. Anderson, D. O. Helton, N. Bodor and E.
Pop, "Dose-Dependent Brain Delivery of Zidovudine Through the Use of a Zidovudine
Chemical Delivery System" Pharm Res., 12, 796-798 (1995).
S. Amselem, D. Friedman, A. Yogev, W. R. Anderson, D. O.
Helton, T. Loftsson, N. Bodor, E. Pop and M. Brewster, "Formulation Development for a
Zidovudine Chemical Delivery System. 2. Towards Oral and Non-Parenteral Dosage Forms"
Int. J. Pharm., 125, 31-34 (1995).
M. E. Brewster, M.-J. Huang, E. Pop and N. Bodor,
"Isomeric Interconversions in Tamoxifen and Related Compounds: an AM1 Study"
Int. J. Quantum Chem., 53, 343-352 (1995).
M.E. Brewster, P.J. Druzgala, W.R. Anderson, M.-J. Huang, N.
Bodor and E. Pop, "Efficacy of a 3-Substituted versus 17-Substituted Chemical
Delivery System for Estradiol Brain Targeting" J. Pharm Sci., 84, 38-43 (1995).
M.E. Brewster, T. Loftsson, S. Amselem, D. Friedman, A.
Yogev, W. R. Anderson, D. O. Helton, A. Dinculescu, N. Bodor and E. Pop "Formulation
Development for a Zidovudine Chemical Delivery System. I. Parenteral Dosage Forms".
Int. J. Pharm., 125, 17-30 (1995).
M.E. Brewster, M.S.M. Bartruff, W.R. Anderson, P. J.
Druzgala, N. Bodor and E. Pop, "Effect of Molecular Manipulation on the Estrogenic
Activity of a Brain-Targeting Estradiol Chemical Delivery System" J. Med. Chem., 37,
4237-4244, (1994).
E. Pop, K. Prokai-Tátrai, M.E. Brewster and N. Bodor, "Analogs of Tryptophan."
Org. Prep. Proc. Int. 26, 715-718 (1994).
W.R. Anderson, A.I. Webb, E. Pop and M. Brewster "Effect of a Cyclodextrin
Formulation for Alfaxalone and Pregnanolone on the Anesthetic Profile in Rats." in
Proceedings of the 7th International Symposium on Cyclodextrins, Business Center for
Academic Societies, Tokyo, pp 467-470 (1994).
M.E. Brewster, C. Kibbey, M.-J. Huang, E. Pop and N. Bodor,
"Interaction of Substituted Phenols and 2-Hydroxypropyl- -cyclodextrin." In
Proceedings of the 7th International Symposium on Cyclodextrins, Business Center for
Academic Societies, Tokyo, pp 250-253 (1994).
E. Pop, M.-J. Huang, M. E. Brewster and N. Bodor
"Stability of 1,3-Substituted 1,4-Dihydropyridines; Substituent Effects on the Acid
Catalyzed Hydration and Oxidation Reactions." Int. J. Quantum Chem. Quantum Biol.
Symposium 21, 173-180 (1994).
E. Pop, Z. Z. Liu, J. Vlasak, W. Anderson, M. E. Brewster and
N. Bodor "A Dihydroisoquinoline Targetor-Based Acid Resistant Chemical Delivery
System of Azidothymidine (AZT)." Drug Delivery, 1, 143-149 (1994).
E. Pop, M.-J. Huang, M. E. Brewster and N. Bodor "On the
Mechanism of Cephalosporin Isomerization." J. Mol. Structure (Theochem), 315, 1-7,
(1994).
M. E. Brewster, A. J. Braunstein, M. S. M. Bartruff, C.
Kibbey, M.-J. Huang, E. Pop and N. Bodor "Solubilization and Electrochemical
Stabilization of Substituted Phenols Through the Use of 2-Hydroxypropyl-
-cyclodextrin." Supramolecular Chemistry, 4, 69-76, (1994).
E. Pop, M. E. Brewster, K. Prokai-Tátrai and N. Bodor
"Preparation of Redox Derivatives of 3 -Hydroxy-5 -Pregnane-11,20-dione" Org.
Prep. Proc. Int., 26, 296-300 (1994).
M. E. Brewster, E. Pop, M.-J. Huang and N. Bodor
"Contributions of Molecular Orbital Techniques to the Study of Dihydropyridines"
Heterocycles, 37, 1373-1415 (1994).
E. Pop, M.E. Brewster, K. Prokai-Tátrai and N. Bodor
"Novel Redox Derivatives of Tryptophan." Heterocycles, 38, 2051-2064 (1994).
M.E. Brewster, K. Raghavan, E. Pop and N. Bodor,
"Brain-Enhanced Delivery of Gancyclovir Through the Use of Redox Targeting."
Antimicrobial Agents & Chemotherapy, 38, 817-823 (1994).
C.T. Supuran, E. Pop and A. Dinculescu, "Reaction of
Pyrilium Salts with Aminoacid Derivatives 3. Ribonuclease Inactivation by Trisubstituted
Pyrilium Salts." Heterocycles, 37, 667-671 (1994).
E. Pop, M.E. Brewster, A. Dinculescu, M.-J. Huang and N.
Bodor, Isomerization of Cephalosporin Esters; Theoretical and Practical Aspects."
Heterocycles, 37, 477-486 (1994).
M. E. Brewster, E. Pop, M.-J. Huang and N. Bodor,
"Rotation Barriers in Phenol and Sterically Congested Phenol Derivatives. An AM1
Study." J. Mol. Structure (Theochem), 303, 25-38 (1994).
W.R. Anderson, M.E. Brewster, E. Pop, K.S. Estes and N.
Bodor, "Improvement of Parenteral Formulations for Traditional Epileptics." PDA
J. Pharm. Sci. Technol., 48, 333-335 (1994).
E. Pop "Targeting Penicillins to the Central Nervous
System." Adv. Drug Deliv. Review, 14, 211-226 (1994).
E. Pop, M.E. Brewster, M.-J. Huang and N. Bodor
"Dihydropyridine Isomerism in the Chemical Delivery System Series." Croat. Chem.
Acta, 66, 321-327, (1993).
E. Pop, M.E. Brewster, M.-J. Huang and N. Bodor, "A
Theoretical Study of the Dithionite Reduction of Pyridium Salts." Int. J. Quantum
Chem. Quantum Biology Symposium 20, 17-24 (1993).
M.E. Brewster, M.-J. Huang, E. Pop and N. Bodor,
"Hydroxyl Stretching in Substituted Phenols: an AM1 Study." Int. J. Quantum
Chem., Quantum Biology Symposium 20, 7-15 (1993).
M. E. Brewster, E. Pop, A. J. Braunstein, A. C. Pop, P.
Druzgala, A. Dinculescu, W. Anderson, A. Elkoussi and N. Bodor, "The Effect of
Dihydronicotinate N-Substitution on the Brain-Targeting Efficacy of a Zidovudine Chemical
Delivery System." Pharm. Res., 10, 1356-1362 (1993).
E. Pop, M.E. Brewster, M.-J Huang and N. Bodor,
"Dithionite Reduction of Pyridinium Salts; an AM1 Study." J. Mol. Structure
(Theochem), 283, 27-32 (1993).
M. E. Brewster, E. Pop and N. Bodor, "Chemical
Approaches to Brain-Targeting of Biologically Active Compounds" In Drug Design for
the Neurosciences, A. P. Kozikowski, (Ed.), Raven Press, New York, NY , pp 435-467 (1993).
L. Prokai, K. Prokai-Tátrai, E. Pop, N. Bodor, J. Lango and
J. Roboz, "Fast Atom Bombardment and Tandem Mass Spectrometry of Quaternary
Pyridinium Salt-Type Tryptophan Derivatives." J. Org. Mass Spectrom., 28, 707-715
(1993).
M. E. Brewster, M.-J. Huang, E. Pop, J. Pitha and N. Bodor,
"Chemical Substitution in Glucose Polymers and Oligomers. A Theoretical (AM1) Study
of -D-Glucose and ß-Maltose." Carbohydrate Res., 242, 53-67 (1993).
E. Pop, M.E. Brewster, W. R. Anderson and N. Bodor
"Biodistribution of Azidothymidine Mediated by a Highly Lipophilic Chemical Delivery
System." Med. Chem. Res., 2, 457-466 (1992).
M. E. Brewster, W. R. Anderson, E. Pop, K. S. Estes and N.
Bodor, "Improved Parenteral Formulations for Traditional Antiepileptics." In
Minutes of the Sixth International Symposium on Cyclodextrins, A. Hedges (Ed), Edition de
Santé, Paris pp 437-441 (1992).
E. Pop, M.-J. Huang, M.E. Brewster and N. Bodor, "A
Theoretical Study of the Hydrolysis of Some Sterically Hindered Phenolic Esters."
Int. J. Quantum Chem., Quantum Biology Symposium 19, 77-85 (1992).
E. Pop and N. Bodor "Chemical Systems for Delivery of
Antiepileptic Drugs to the Central Nervous System." Epilepsy Res., 13, 1-16 (1992).
E. Pop, W. Anderson, J. Vlasak, M. E. Brewster and N. Bodor,
"Enhanced Brain Delivery of 2'-Fluoro-5-methyl-arabinosyluracil (FMAU)." Int. J.
Pharmaceutics, 84, 39-48 (1992).
E. Pop, W. Anderson, K. Prokai-Tátrai, M.E. Brewster and N.
Bodor, "Synthesis and Preliminary Pharmacological Evaluation of Some Chemical
Delivery Systems of 2,3-Diisopropylphenol (Propofol)." Med. Chem. Res., 2, 16-21
(1992).
E. Pop, W. Anderson, M.E. Brewster and N. Bodor,
"Enhanced Monoamine Oxidase Inhibitor Activity of Tranylcypromine." Med. Chem.
Res, 1, 230-234 (1991).
M. E. Brewster, M.-J. Huang, J. J. Kaminski, E. Pop and N.
Bodor, "Reactivity of Biologically Important Reduced Pyridines VIII. A Semiempirical
(AM1) Study of the Oxidation of 3-Substituted-1-Methyl-1,4-Dihydropyridines."
Computational Chemistry, 12, 1278-1282 (1991).
E. Pop, M.E. Brewster and N. Bodor, "Site Specific
Delivery of the Centrally Acting Amines." Drugs Fut. 16, 919-944 (1991).
E. Pop, M-J. Huang, S. Matei, M.E. Brewster and N. Bodor,
"Electrophilic Substitution in Benzofuran Series; A Theoretical (AM1) Study."
Int. J. Quantum Chem. 1991, Quantum Chemistry Symposium 25, 325-333 (1991).
W. R. Anderson, E. Pop, S.-K. Lee, M. Bhagrath, N. Bodor and
M.E. Brewster "Brain-Enhanced Delivery of Adenosine Depresses Locomotor Behavior in
Rats." Med. Chem. Res. 1, 74-79 (1991).
M. E. Brewster, D.R. Doerge, M-J. Huang, J.J. Kaminski, E.
Pop and N. Bodor, "Application of Semiempirical Molecular Orbital Techniques to the
Study of Peroxide-Mediated Oxidation of Phenols, Anilines, Sulfides and
Thiobenzamides." Tetrahedron, 47, 7525-7536 (1991).
M. E. Brewster, M-J. Huang, J.J. Kaminski, E. Pop and N.
Bodor, "Use of Semiempirical Molecular Orbital Parameters to Prove Dihydropyridine
Stability-Implications to Brain-Targeting Chemical Delivery System." Rev. Roumaine
Chim. 36, 647-656 (1991).
E. Pop, M.E. Brewster and N. Bodor, "Improved Central
Nervous Systems Delivery and Activity of Antiepileptic Drugs." Drugs Fut., 16,
221-248 (1991).
E. Pop, S. Bercovici, M-J. Huang, S. Shatzmiller and N.
Bodor, "Ionic and Radical Intermediates of 3-Substituted
5,6-Dihydro-1,4,2-Dioxazines; A Theoretical (AM1) Study." J. Mol. Structure
(Theochem), 235, 343-353 (1991).
E. Pop, T. Loftsson and N. Bodor, "Solubilization and
Stabilization of a Benzylpenicillin Chemical Delivery System by
2-Hydroxypropyl-ß-cyclodextrin." Pharm. Res. 8, 1044-1049 (1991).
E. Pop, K. Prókai-Tátrai, W. Anderson, M. E. Brewster and
N. Bodor, "Redox Analogs of Centrally Acting Amines Design, Synthesis and Properties
of a Tranylcypromine Derivative with Potentially Enhanced Therapeutic Index." J.
Biopharm. Sci. 2, 11-23 (1991).
K. Prokai-Tátrai, E. Pop, W. Anderson, J.L. Lin, M.E.
Brewster and N. Bodor, "Redox Derivatives of Tranylcypromine: Syntheses, Properties
and Monoamine Oxidase Inhibitor Activity of Some Chemical Delivery Systems." J.
Pharm. Sci., 80, 255-261 (1990).
E. Pop, K. Prokai-Tátrai, W. Anderson, J.L. Lin, M.E.
Brewster and N. Bodor, "Application of the Brain Specific Chemical Delivery System
Approach to Tranylcypromine." Eur. J. Pharmacol., 183, 1909 (1990).
E. Pop, W. Anderson, K. Prokai-Tátrai, M.E. Brewster, M.
Fregly and N. Bodor, "Antihypertensive Activity of Redox Derivatives of
Tryptophan." J. Med. Chem., 33, 2216-21 (1990).
E. Pop, M.E. Brewster and N. Bodor, "Central Nervous
System Enhanced Delivery of ß-Lactam Antibiotics." Drugs Fut. 15, 473-492 (1990).
E. Pop, K. Prokai-Tátrai, J.D. Scott, M.E. Brewster and N.
Bodor, "Application of a Brain-Targeting Chemical Delivery System to
9-Amino-1,2,3,4-tetrahydroacridine." Pharm. Res., 7, 662-668 (1990).
E. Pop, T. Loftsson and N. Bodor, "Novel Central Nervous
System Targeted Semisynthetic Penicillins." Drug Design Deliv., 5, 221-237 (1990).
W.-M. Wu, E. Pop, E. Shek, R. Clemmons and N. Bodor,
"Brain and CSF Specific Chemical Delivery Systems for ß-Lactamic Antibiotics. In
Vitro and In Vivo Studies of Dihydropyridine Derivatives of Benzylpenicillin in Rabbits
and Dogs." Drug Design Deliv., 7, 33-43 (1990).
M. E. Brewster, C. Robledo-Luiggi, A. Miyakeb, E. Pop and N.
Bodor, "Brain Enhanced Delivery of Anti-Dementia Drugs." In "Novel
Approaches to the Treatment of Alzheimer's Disease." E. Meyer (Ed.), Plenum Press, p.
173-183, 1989.
E. Pop, M.E. Brewster, J.J. Kaminski and N. Bodor,
"Theoretical Aspects of Cephalosporin Isomerization." Int. J. Quantum Chem.;
Quantum Biol. Symposium 16, John Wiley & Sons, Inc., 291-300, 1989.
E. Pop, W-M. Wu, E. Shek and N. Bodor, "Chemical
Delivery Systems for Drugs Containing an Amino Group; Syntheses and Properties of Some
Pyridine Derivatives of Desipramine." Drug Design Deliv., 5, 93-115 (1989).
E. Pop, W-M. Wu and N. Bodor, "Chemical Delivery Systems
for Some Penicillinase Resistant Semisynthetic Penicillins." J. Med. Chem., 32,
1789-1795 (1989).
W.-M. Wu, E. Pop, E. Shek and N. Bodor, "Brain Specific
Chemical Delivery Systems for ß-Lactam Antibiotics. In Vitro and In Vivo Studies of Some
Dihydropyridine and Dihydroisoquinoline Derivatives of Benzylpenicillin." J. Med.
Chem., 32, 1782-1789 (1989).
E. Pop, W-M. Wu, E. Shek and N. Bodor, "Brain Specific
Chemical Delivery Systems for ß-Lactam Antibiotics. Synthesis and Properties of Some
Dihydropyridine and Dihydroisoquinoline Derivatives of Benzylpenicillin." J. Med.
Chem., 32, 1774-1781 (1989).
E. Pop, M.E. Brewster, J.J. Kaminski and N. Bodor,
"Theoretical Study of Some Heterocyclic Amines with Applications to the Chemistry of
9-Amino-1,2,3,4-tetrahydroacridine (THA)." Int. J. Quantum Chem., 35, 315-324 (1989).
E. Shek, T. Murakami, C. Nath, E. Pop and N. Bodor,
"Improved Anticonvulsant Activity of Phenytoin by a Redox Brain Delivery System;
Brain Uptake and Pharmacological Effects." J. Pharm. Sci., 78, 837-843 (1989).
T. Murakami, E. Shek, E. Pop and N. Bodor, "Improved
Anticonvulsant Activity of Phenytoin by a Redox Brain Delivery System; Stability in
Buffers and Biological Materials." J. Pharm. Sci., 78, 732-737 (1989).
E. Pop, E. Shek, T. Murakami and N. Bodor, "Improved
Anticonvulsant Activity of Phenytoin by a Redox Brain Delivery System; Synthesis and Some
Properties of the Dihydropyridine Derivatives." J. Pharm. Sci., 78, 609-616 (1989).
D. Breazu, M. Sclifos, E. Pop and R. Miloia,
"Contributions to the Syntheses of Some Tricyclic Psychotropic Products." Rev.
Chim. (Bucharest) 36, 617 (1985).
E. Pop, L. Beu and R.D. Pop, "The Structure of Some
-Cyanoglyoxylic Ester Phenylhydrazones." Rev. Roumaine Chim., 24, 1061 (1979).
E. Pop, "Structure-Biological Activity Relationship of
Some Furocoumarine Derivatives." In Proceedings of the Symposium
"Structure-Activity Relationships of Synthetic Compounds" C. Bodea (Ed.)
Academia R.S. Romania, Filiala Cluj, pp. 111-119 (1979).
M. Sclifos, E. Pop and B. Kovacs, "Ketopregnane
Derivatives with Therapeutic Activity." In Proceedings of the First Symposium of the
Original Romanian Drug, Bucharest, Editura Medicala Bucharest, pp. 289-291 (1978).
E. Pop, "The Study of the Structures and Properties of
Some Heterocyclic and Steroid Isomers." Doctor's Thesis, Institute of Chemistry,
Cluj, 1973.
E. Pop, N. Trinajstic and L. Klasinc, "Theoretical
Studies of Some Furocoumarine Isomers." Rev. Roumaine Chim., 18, 1249-1257 (1973).
L. Klasinc, N. Trinajstic and E. Pop, "Theoretical Study
of Isomeric Thienylfurans." Rev. Roumaine Chim., 18, 89-98 (1973).
L. Klasinc, E. Pop, N. Trinajstic and J.V. Knop,
"Theoretical Studies of Positional Isomers Obtained by Annelation of Benzene and
5-Membered Ring Heterocyclics Containing N, O or S." Tetrahedron, 28, 3465-3474
(1972).
N. Bodor, E. Pop and N. Trinajstic, "Valence Shell and
Electron SCFMO Calculation for the Isomerism of the 21-Benzylidene-20-oxo-pregnane
Derivatives." Rev. Roumaine Chim., 16, 1427-1433 (1971). |