Jing Yang

Jing Yang, Ph.D.

Dr. Jing Yang, Director of Quality Control, received her undergraduate training as an Analytical Chemist at Shanghai University. After several years of work in an analytical laboratory at the University of Florida, Gainesville, FL, and at ABC Research Company in Gainesville, FL, she continued with graduate studies in Organic Chemistry at the University of Florida, receiving her Ph. D. in Chemistry in 1995. Before Dr. Yang joined Alchem Laboratories in 1999 as a Senior Research Scientist, she received additional experience during a post-doctoral fellowship and two years of work in a custom research organization, where she was mainly involved in organic synthesis. At Alchem Laboratories, Dr. Yang was first responsible for API synthesis and process development. In 2001, she was promoted to Group Leader, Process Development, and successfully brought a number of pharmaceutical products from laboratory to kilogram scale production. Dr. Yang became Associate Director of Quality Control (2004) and later Director of Quality Control (2006). Dr. Yang is responsible for all Quality Control work performed within Alchem Laboratories.

Publications:

1) Oniciu, D. C.; Pop, E.; Dasseux, J.-L. H.; Mueller, R.; Yang, J.; Bell, R. P. L.; Regeling, H.; Ebbers, E. J.; Leemhuis, F. M. C.; Cramer, C. T.; Goetz, B.; Pape, M. E.; Bisgaier, C. L. Long hydrocarbon chain diols and diacids with central ether or ketone moieties that favorably alter lipid disorders. Pharmazie 2006, 61, 157-165.

2) Oniciu, D. C.; Dasseux, J.-L. H.; Yang, J.; Mueller, R.; Pop, E.; Denysenko, A.; Duan, C.; Huang, T.-B.; Zhang, L.; Krause, B. R.; Drake, S. L.; Lalwani, N.; Cramer, C. T.; Goetz, B.; Pape, M. E.; McKee, A.; Fici, G. J.; Lutostanski, J. M.; Brown, S. C.; Bisgaier, C. L. Influence of Various Central Moieties on the Hypolipidemic Properties of Long Hydrocarbon Chain Diols and Diacids. J. Med. Chem. 2006, 49, 334-348.

3) Yang, J.; Mueller, R.; Pop, E.; Dasseux, J.-L. H.; Oniciu; D. C. Kilogram-Scale Synthesis of Bis(6-hydroxy-5,5-dimethylhexyl)ether (ESP24232), a Novel Lipid Lowering Agent. Org. Prep. Proc. Int. 2004, 36, 587-596.

4) Mueller, R.; Yang, J.; Duan, C.; Pop, E.; Geoffroy, O. J.; Zhang, L. H.; Huang, T.-B.; Denisenko, S.; McCosar, B. H.; Oniciu, D. C.; Bisgaier, C. L.; Pape, M. E.; Freiman, C. D.; Goetz, B.; Cramer, C. T.; Hopson, K. L.; Dasseux, J.-L. H. Long Hydrocarbon Chain Keto Diols and Diacids that Favorably Alter Disorders In Vivo”. J. Med. Chem. 2004, 47, 6082-6099.

5) Mueller, R.; Yang, J.; Duan, C.; Pop, E.; Zhang, L. H.; Huang, T.-B.; Denysenko, A.; Denisko, O. V.; Oniciu, D. C.; Bisgaier, C. L.; Pape, M. E.; Freiman, C. D.; Goetz, B.; Cramer, C. T.; Hopson, K. L.; Dasseux, J.-L. H. Long Hydrocarbon Chain Ether Diols and Ether Diacids that Favorably Alter Lipid Disorders In Vivo. J. Med. Chem. 2004, 47, 5183-5197.

6) Mueller, R.; Yang, J.; Pop, E.; Duan, C.; Oniciu, D. C.; Bisgaier, C. L.; Pape, M. E.; Goetz, B.; Cramer, C. T.; Dasseux, J.-L. H. Long Hydrocarbon Chain Diols and Diacids with Central Ether or Ketone Moieties that Favorably Alter Lipid Disorders in Vivo. International Symposium on Medicinal Chemistry, Copenhagen, Denmark and Malmö, Sweden, 2004.

7) Yang, J.; Jones, W. M. First Evidence for the existence of a Ruthenabenzene. J. Am. Chem. Soc. 1995, 116, 3265.

8) Yang, J.; Yin, J.; Abboud, K. A.; Jones, W. M. Metallaindenes of Molybenum, Tungsten and Ruthenium. Organometallics 1994, 13, 971.

9) Trace, R. L.; Sanchez, J.; Yang, J.; Yin, J.; Jones, W. M. Carbene Migratory Insertion: Preparation of the First Second Row Late Transition Metal Alkyl Substituted Carbene Complex and Comparison of its Migratory Insertion with its Iron Analogue. Organometallics 1992, 11, 1440.