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Jing Yang, Ph.D.   

Dr. Jing Yang, Director of Quality Control, received her undergraduate training in analytical chemistry at Shanghai University and a Ph.D in organometallic chemistry from the University of Florida. Joining Alchem in 1999 Dr. Yang was first responsible for API synthesis and process development and was promoted in 2001 to Group Leader for process development and GMP manufacturing of late-stage-experimental products. She was appointed to her current position in 2006.

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Publications:

1)   Oniciu, D. C.; Pop, E.; Dasseux, J.-L. H.; Mueller, R.; Yang, J.; Bell, R. P. L.; Regeling, H.; Ebbers, E. J.; Leemhuis, F. M. C.; Cramer, C. T.; Goetz, B.; Pape, M. E.; Bisgaier, C. L. Long hydrocarbon chain diols and diacids with central ether or ketone moieties that favorably alter lipid disorders. Pharmazie 2006, 61, 157-165.

2)   Oniciu, D. C.; Dasseux, J.-L. H.; Yang, J.; Mueller, R.; Pop, E.; Denysenko, A.; Duan, C.; Huang, T.-B.; Zhang, L.; Krause, B. R.; Drake, S. L.; Lalwani, N.; Cramer, C. T.; Goetz, B.; Pape, M. E.; McKee, A.; Fici, G. J.; Lutostanski, J. M.; Brown, S. C.; Bisgaier, C. L. Influence of Various Central Moieties on the Hypolipidemic Properties of Long Hydrocarbon Chain Diols and Diacids. J. Med. Chem. 2006, 49, 334-348.

3)   Yang, J.; Mueller, R.; Pop, E.; Dasseux, J.-L. H.; Oniciu; D. C. Kilogram-Scale Synthesis of Bis(6-hydroxy-5,5-dimethylhexyl)ether (ESP24232), a Novel Lipid Lowering Agent. Org. Prep. Proc. Int. 2004, 36, 587-596.

4)   Mueller, R.; Yang, J.; Duan, C.; Pop, E.; Geoffroy, O. J.; Zhang, L. H.; Huang, T.-B.; Denisenko, S.; McCosar, B. H.; Oniciu, D. C.; Bisgaier, C. L.; Pape, M. E.; Freiman, C. D.; Goetz, B.; Cramer, C. T.; Hopson, K. L.; Dasseux, J.-L. H. Long Hydrocarbon Chain Keto Diols and Diacids that Favorably Alter Disorders In Vivo”. J. Med. Chem. 2004, 47, 6082-6099.

5)    Mueller, R.; Yang, J.; Duan, C.; Pop, E.; Zhang, L. H.; Huang, T.-B.; Denysenko, A.; Denisko, O. V.; Oniciu, D. C.; Bisgaier, C. L.; Pape, M. E.; Freiman, C. D.; Goetz, B.; Cramer, C. T.; Hopson, K. L.; Dasseux, J.-L. H. Long Hydrocarbon Chain Ether Diols and Ether Diacids that Favorably Alter Lipid Disorders In Vivo. J. Med. Chem. 2004, 47, 5183-5197.

6)   Mueller, R.; Yang, J.; Pop, E.; Duan, C.; Oniciu, D. C.; Bisgaier, C. L.; Pape, M. E.; Goetz, B.; Cramer, C. T.; Dasseux, J.-L. H. Long Hydrocarbon Chain Diols and Diacids with Central Ether or Ketone Moieties that Favorably Alter Lipid Disorders in Vivo. International Symposium on Medicinal Chemistry, Copenhagen, Denmark and Malmö, Sweden, 2004.

7)   Yang, J.; Jones, W. M. First Evidence for the existence of a Ruthenabenzene. J. Am. Chem. Soc. 1995, 116, 3265.

8)   Yang, J.; Yin, J.; Abboud, K. A.; Jones, W. M. Metallaindenes of Molybenum, Tungsten and Ruthenium. Organometallics 1994, 13, 971.

9)   Trace, R. L.; Sanchez, J.; Yang, J.; Yin, J.; Jones, W. M. Carbene Migratory Insertion: Preparation of the First Second Row Late Transition Metal Alkyl Substituted Carbene Complex and Comparison of its Migratory Insertion with its Iron Analogue. Organometallics 1992, 11, 1440.

 


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